Abstract
Two new 14-desoxo-10, 18-dihydromyrinsol diterpenoids (1 and 2) were isolated and characterized from the cytotoxic chloroform fraction of Euphorbia aellenii Rech. f. (Euphorbiaceae). The structures of the new compounds were elucidated by spectroscopic methods and their immunomodulatory properties were evaluated by T-cell proliferation and phagocyte chemiluminescence assays.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Dose-Response Relationship, Drug
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Euphorbia / chemistry*
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Humans
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Immunologic Factors / chemistry
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Immunologic Factors / isolation & purification*
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Immunologic Factors / pharmacology*
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Iran
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Luminescent Measurements
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phagocytes / drug effects*
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Phytohemagglutinins / pharmacology
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Reactive Oxygen Species / metabolism
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T-Lymphocytes / drug effects
Substances
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14-desoxo-3alpha,5alpha,7beta,10,15beta-O-pentaacetyl-14beta-O-butanoyl-10,18-dihydromyrinsol
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14-desoxo-3beta,5alpha,7beta,10,15beta-O-pentaacetyl-14alpha-O-benzoyl-10,18-dihydromyrinsol
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Diterpenes
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Immunologic Factors
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Phytohemagglutinins
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Reactive Oxygen Species