Increased thrombin generation measured in the presence of thrombomodulin in women with early pregnancy loss

Luc de Saint Martin; Jérôme Duchemin; Caroline Bohec; Francis Couturaud; Dominique Mottier; Michel Collet; Marie-Thérèse Blouch; Elisabeth Pasquier

doi:10.1016/j.fertnstert.2010.11.019

Increased thrombin generation measured in the presence of thrombomodulin in women with early pregnancy loss

Fertil Steril. 2011 Apr;95(5):1813-5.e1. doi: 10.1016/j.fertnstert.2010.11.019. Epub 2010 Dec 3.

Authors

Luc de Saint Martin¹, Jérôme Duchemin, Caroline Bohec, Francis Couturaud, Dominique Mottier, Michel Collet, Marie-Thérèse Blouch, Elisabeth Pasquier

Affiliation

¹ Department of Internal Medicine and Chest Diseases, Brest University Hospital, La Cavale Blanche Hospital, Brest, France.

PMID: 21130429
DOI: 10.1016/j.fertnstert.2010.11.019

Abstract

Compared with 537 parous controls with no history of pregnancy loss, a lower thrombomodulin-related inhibition of the endogenous thrombin potential was measured in 264 cases with previous unexplained pregnancy loss, especially when losses occurred between 9 and 12 weeks of gestation. Adjusting age, protein S, factor VIII, factor V Leiden, and prothrombin G20210A did not change the results.

MeSH terms

Adult
Case-Control Studies
Embryo Loss / blood
Embryo Loss / metabolism*
Female
Humans
Pregnancy
Pregnancy Trimester, First / blood
Pregnancy Trimester, First / metabolism*
Thrombin / analysis
Thrombin / metabolism*
Thrombomodulin / metabolism*
Up-Regulation

Substances

THBD protein, human
Thrombomodulin
Thrombin