Amyloid beta-protein precursor is associated with extracellular matrix

F G Klier; G Cole; W Stallcup; D Schubert

doi:10.1016/0006-8993(90)90619-m

Amyloid beta-protein precursor is associated with extracellular matrix

Brain Res. 1990 May 7;515(1-2):336-42. doi: 10.1016/0006-8993(90)90619-m.

Authors

F G Klier¹, G Cole, W Stallcup, D Schubert

Affiliation

¹ La Jolla Cancer Research Foundation, CA.

PMID: 2113416
DOI: 10.1016/0006-8993(90)90619-m

Abstract

The ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Amyloid / metabolism*
Amyloid beta-Protein Precursor
Animals
Cell Line
Extracellular Matrix / metabolism*
Neurons / metabolism*
Neurons / ultrastructure
Protein Precursors / metabolism*
Rats

Substances

Amyloid
Amyloid beta-Protein Precursor
Protein Precursors