Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions

Susan L Baldwin; Christopher B Fox; Mark A Pallansch; Rhea N Coler; Steven G Reed; Martin Friede

doi:10.1016/j.vaccine.2010.11.043

Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions

Vaccine. 2011 Jan 17;29(4):644-9. doi: 10.1016/j.vaccine.2010.11.043. Epub 2010 Dec 4.

Authors

Susan L Baldwin¹, Christopher B Fox, Mark A Pallansch, Rhea N Coler, Steven G Reed, Martin Friede

Affiliation

¹ Infectious Disease Research Institute, 1124 Columbia St, Suite 400, Seattle, WA 98104, USA. [email protected]

PMID: 21134451
DOI: 10.1016/j.vaccine.2010.11.043

Abstract

The use of inactivated poliovirus vaccines (IPV) will be required to achieve, world-wide eradication of polio. The current expense of IPV is however prohibitive for, some countries, and therefore efforts to decrease the costs of the vaccine are a high, priority. Our results show that the addition of oil-in-water emulsion adjuvants to an, inactivated trivalent poliovirus vaccine are dose-sparing and are capable of enhancing, neutralizing antibody titers in the rat potency model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / administration & dosage*
Animals
Antibodies, Neutralizing / blood
Antibodies, Viral / blood
Emulsions / administration & dosage
Female
Oils / administration & dosage*
Poliovirus Vaccines / administration & dosage
Poliovirus Vaccines / immunology*
Rats
Rats, Wistar
Vaccination / methods*
Vaccines, Inactivated / administration & dosage
Vaccines, Inactivated / immunology
Water / administration & dosage

Substances

Adjuvants, Immunologic
Antibodies, Neutralizing
Antibodies, Viral
Emulsions
Oils
Poliovirus Vaccines
Vaccines, Inactivated
Water