Controversies in loco-regional treatment: post-mastectomy radiation for pT2-pT3N0 breast cancer arguments in favour

Maria Carla Valli; Association of Radiotherapy and Oncology of the Mediterranean arEa (AROME)

doi:10.1016/j.critrevonc.2010.11.002

Controversies in loco-regional treatment: post-mastectomy radiation for pT2-pT3N0 breast cancer arguments in favour

Crit Rev Oncol Hematol. 2012 Dec:84 Suppl 1:e70-4. doi: 10.1016/j.critrevonc.2010.11.002. Epub 2010 Dec 4.

Authors

Maria Carla Valli¹; Association of Radiotherapy and Oncology of the Mediterranean arEa (AROME)

Affiliation

¹ Radiation Oncology Department, Oncology Institute of Southern Switzerland, Switzerland. [email protected]

PMID: 21134765
DOI: 10.1016/j.critrevonc.2010.11.002

Abstract

Post-mastectomy RT decreases the rate of locoregional recurrences of about 70% in all patients irrespective of age, tumor characteristics or systemic therapy. Post-mastectomy RT has to be proposed, moreover when locoregional lymph nodes are part of the PTV, if an optimal coverage of the PTV and a satisfactory sparing of the OAR could be obtained. Due to the results of meta-analysis, consensus conferences and randomized trials the long-term efficacy of RT in decreasing the risk of LRF is well established and the vast majority of women, treated with mastectomy, will benefit from it.

Publication types

Review

MeSH terms

Breast / pathology
Breast / radiation effects*
Breast / surgery*
Breast Neoplasms / pathology
Breast Neoplasms / radiotherapy*
Breast Neoplasms / surgery*
Female
Humans
Lymph Nodes / pathology
Lymph Nodes / radiation effects
Mastectomy
Neoplasm Recurrence, Local / pathology
Neoplasm Recurrence, Local / radiotherapy
Neoplasm Recurrence, Local / surgery