Novel H1N1 influenza A virus infection in a patient with acute rejection after liver transplantation

Hepatobiliary Pancreat Dis Int. 2010 Dec;9(6):658-60.

Abstract

Background: The 2009 H1N1 influenza A virus was first identified in April 2009 and rapidly evolved into a pandemic. Recipients of solid-organ transplants have a higher risk for severe infection because of immunosuppression. There are limited reports of 2009 H1N1 influenza in liver transplant recipients, especially in China.

Methods: We present a case of a 48-year-old male liver transplant recipient with 2009 H1N1 influenza A virus. He received therapy for acute rejection after transplantation and was confirmed with H1N1 virus infection.

Results: The patient was started on oseltamivir (75 mg, orally twice daily) and had a benign hospital course, with defervescence and resolution of symptoms within 72 hours. The follow-up chest radiograph after discharge was normal.

Conclusions: The 2009 H1N1 influenza in this hospitalized transplant recipient was relatively mild, and prolonged viral shedding was not noted. Oseltamivir can be a valid measure in immunocompromised individuals.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Antiviral Agents / therapeutic use
  • Graft Rejection / complications*
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human / complications*
  • Influenza, Human / drug therapy
  • Liver Transplantation*
  • Male
  • Middle Aged
  • Oseltamivir / therapeutic use

Substances

  • Antiviral Agents
  • Oseltamivir