Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October-November 2010

G Grard; J F Drexler; S Lekana-Douki; M Caron; A Lukashev; D Nkoghe; J P Gonzalez; C Drosten; E Leroy

doi:10.2807/ese.15.47.19723-en

Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October-November 2010

Euro Surveill. 2010 Nov 25;15(47):19723. doi: 10.2807/ese.15.47.19723-en.

Authors

G Grard¹, J F Drexler, S Lekana-Douki, M Caron, A Lukashev, D Nkoghe, J P Gonzalez, C Drosten, E Leroy

Affiliation

¹ Centre International de Recherches Medicales de Franceville (CIRMF, International Centre of Medical Research of Francville), Franceville, Gabon.

PMID: 21144443
DOI: 10.2807/ese.15.47.19723-en

Abstract

An outbreak of flaccid paralysis syndrome in adults is ongoing in Congo. Molecular analysis of faecal, throat and cerebrospinal samples identified wildtype 1 poliovirus and an additional enterovirus C strain related to enterovirus 109 as the cause. As of 22 November, the cumulative number of cases was 409, of which 169 (41.3%) were fatal. This is one of the largest wild type 1 poliovirus outbreaks ever described associated with an unusually high case fatality rate.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adult
Congo / epidemiology
Disease Outbreaks
Enterovirus C, Human / genetics
Enterovirus C, Human / isolation & purification*
Enterovirus Infections / epidemiology*
Enterovirus Infections / virology
Genome, Viral
Humans
Molecular Sequence Data
Paralysis / complications
Paralysis / epidemiology*
Paralysis / virology
Poliomyelitis / epidemiology*
Poliomyelitis / etiology
Poliomyelitis / virology
Poliovirus / isolation & purification*
Polymerase Chain Reaction
Population Surveillance
Sequence Analysis, DNA