Abstract
Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents / therapeutic use
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Apoptosis / genetics*
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Apoptosis Regulatory Proteins / antagonists & inhibitors
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CASP8 and FADD-Like Apoptosis Regulating Protein / physiology
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Caspase 9 / metabolism
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Down-Regulation
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Drug Resistance, Neoplasm / genetics
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Humans
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Intracellular Signaling Peptides and Proteins / physiology
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MicroRNAs / physiology*
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Myeloid Cell Leukemia Sequence 1 Protein
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Neoplasms / drug therapy
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Neoplasms / genetics*
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Peptide Fragments / metabolism
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Phosphoproteins / physiology
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Tumor Suppressor Protein p53 / metabolism
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bcl-X Protein / antagonists & inhibitors
Substances
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Antineoplastic Agents
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Apoptosis Regulatory Proteins
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BCL2L1 protein, human
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BCL2L2 protein, human
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Bax protein (53-86)
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CASP8 and FADD-Like Apoptosis Regulating Protein
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CFLAR protein, human
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Intracellular Signaling Peptides and Proteins
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MicroRNAs
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Myeloid Cell Leukemia Sequence 1 Protein
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PEA15 protein, human
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Peptide Fragments
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Phosphoproteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Tumor Suppressor Protein p53
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bcl-X Protein
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Caspase 9