Abstract
Recent in vitro studies suggest that acyclovir may directly inhibit HIV-1 replication and can select for a specific HIV-1 reverse transcriptase mutation (V75I) with concomitant loss of an anti-HIV-1 effect. We tested for HIV-1 genotypic resistance at reverse transcriptase codon 75 in plasma from 168 HIV-1-infected persons from Botswana, Kenya, Peru, and the United States taking daily acyclovir or valacyclovir for between 8 weeks and 24 months. No V75I cases were detected (95% confidence interval, 0%-2.2%). These prospective in vivo studies suggest that standard-dose acyclovir or valacyclovir does not select for HIV-1 resistance.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / administration & dosage*
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Acyclovir / analogs & derivatives*
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Acyclovir / pharmacology
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Adult
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Amino Acid Substitution / genetics
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Antiviral Agents / administration & dosage*
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Antiviral Agents / pharmacology
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Botswana
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Drug Resistance, Viral*
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Female
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HIV Infections / complications*
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HIV Infections / virology
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HIV Reverse Transcriptase / genetics
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HIV-1 / drug effects*
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HIV-1 / genetics
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HIV-1 / isolation & purification
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Herpes Genitalis / complications*
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Herpes Genitalis / drug therapy
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Herpes Genitalis / virology
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Herpesvirus 2, Human / isolation & purification
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Humans
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Kenya
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Male
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Middle Aged
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Molecular Sequence Data
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Mutation, Missense
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Peru
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Point Mutation
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Prospective Studies
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Selection, Genetic
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Sequence Analysis, DNA
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United States
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Valacyclovir
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Valine / administration & dosage
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Valine / analogs & derivatives*
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Valine / pharmacology
Substances
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Antiviral Agents
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reverse transcriptase, Human immunodeficiency virus 1
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HIV Reverse Transcriptase
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Valine
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Valacyclovir
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Acyclovir
Associated data
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GENBANK/HQ257146
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