Abstract
The damage to the small bowel mucosal barrier was studied prospectively in 26 patients undergoing bone marrow transplantation. The conditioning regimens resulted in the small bowel mucosa becoming more permeable for up to 4 weeks. Acute graft-versus-host disease also compromised barrier function. There was no difference in gut damage between conditioning with chemotherapy only and chemoradiotherapy, but damage was greater in patients 30 years of age and above.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adolescent
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Adult
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Antineoplastic Agents / therapeutic use
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Biological Transport / physiology
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Bone Marrow Transplantation / physiology*
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Cell Membrane Permeability / drug effects
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Cell Membrane Permeability / physiology
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Digestive System / cytology
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Digestive System / drug effects
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Digestive System Physiological Phenomena*
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Graft vs Host Disease / drug therapy
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Graft vs Host Disease / radiotherapy
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Humans
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Lactulose / metabolism
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Mannitol / metabolism
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Middle Aged
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Mucous Membrane / cytology
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Mucous Membrane / drug effects
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Mucous Membrane / physiology
Substances
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Antineoplastic Agents
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Mannitol
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Lactulose