Abstract
Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of amyloid deposits. The release of soluble amyloid beta-protein precursor could be involved in normal platelet physiology.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amyloid / immunology
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Amyloid / metabolism*
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Amyloid beta-Protein Precursor
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Blood Platelets / metabolism*
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Blotting, Western
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Humans
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In Vitro Techniques
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Ionomycin / pharmacology
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Platelet Activation / drug effects
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Platelet Activation / physiology*
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Protein Precursors / immunology
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Protein Precursors / metabolism*
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Thrombin / pharmacology
Substances
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Amyloid
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Amyloid beta-Protein Precursor
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Protein Precursors
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Ionomycin
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Thrombin