Abstract
A proof of concept for the simultaneous multi-parameter determination of three inflammation and sepsis parameters-TNFα, PCT and CRP-using a compact optical immunosensor is demonstrated. Harmonized assay conditions revealed standard curves with test midpoints (IC(50)) of 380 µg L(-1) for TNFα, 2300 µg L(-1) for PCT, and 2645 µg L(-1) for CRP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers / analysis
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Biomarkers / chemistry
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Biosensing Techniques / methods*
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C-Reactive Protein / analysis*
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C-Reactive Protein / chemistry
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Calcitonin / analysis*
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Calcitonin / chemistry
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Humans
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Immunoassay / methods*
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Inflammation / metabolism
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Lasers
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Molecular Weight
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Optical Phenomena
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Point-of-Care Systems*
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Protein Precursors / analysis*
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Protein Precursors / chemistry
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Tumor Necrosis Factor-alpha / analysis*
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Tumor Necrosis Factor-alpha / chemistry
Substances
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Biomarkers
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Protein Precursors
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Tumor Necrosis Factor-alpha
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Calcitonin
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C-Reactive Protein