Can we use imipenem and meropenem Vitek 2 MICs for detection of suspected KPC and other-carbapenemase producers among species of Enterobacteriaceae?

J Clin Microbiol. 2011 Feb;49(2):697-701. doi: 10.1128/JCM.01178-10. Epub 2010 Dec 15.

Abstract

Imipenem and meropenem Vitek 2 MICs were evaluated for a panel of 104 Enterobacteriaceae for identification of carbapenemase producers. The sensitivity and specificity values for the new CLSI interpretative criteria (CLSI document M100-S20-U, 2010) were 98% and 83% for imipenem and 76% and 83% for meropenem, respectively. We propose an algorithm that is highly sensitive (98%) and specific (94%) for carbapenemase screening based on the combined use of imipenem and meropenem MICs.

Publication types

  • Evaluation Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / analysis*
  • Enterobacteriaceae / enzymology*
  • Humans
  • Imipenem / pharmacology*
  • Meropenem
  • Microbial Sensitivity Tests / methods
  • Sensitivity and Specificity
  • Thienamycins / pharmacology*
  • beta-Lactamases / analysis*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Thienamycins
  • Imipenem
  • beta-Lactamases
  • carbapenemase
  • Meropenem