Enantioselective intramolecular Rauhut-Currier reaction catalyzed by chiral phosphinothiourea

Chem Commun (Camb). 2011 Feb 7;47(5):1491-3. doi: 10.1039/c0cc04412a. Epub 2010 Dec 15.

Abstract

Chiral organophosphine-catalyzed enantioselective Rauhut-Currier reaction has been disclosed for the first time. With L-valine-derived phosphinothiourea, the intramolecular Rauhut-Currier reaction of bis(enones) was achieved in good yields (up to 99%) with excellent enantioselectivities (up to 99.4% ee).