One allele's loss is another's gain: alterations of NKX2-8 in non-small cell lung cancer

Clin Cancer Res. 2011 Feb 15;17(4):638-9. doi: 10.1158/1078-0432.CCR-10-3081. Epub 2010 Dec 16.

Abstract

Large-scale genetic changes such as loss or gain of chromosomes are important drivers of solid tumor carcinogenesis. Recent technological advances in genomic profiling have allowed quantitative detection of gene copy numbers, leading to identification of the 14q13.3 gene locus as functionally important in non-small cell lung cancers.

Publication types

  • Comment

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Homeodomain Proteins / genetics*
  • Humans
  • Loss of Heterozygosity*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics*
  • Molecular Targeted Therapy
  • Transcription Factors / genetics*

Substances

  • Homeodomain Proteins
  • NKX2-8 protein, human
  • Transcription Factors