lck suppresses gene expression from various promoters including human T-cell leukemia virus type I promoter

M Ohta; T Morita; K Shimotohno

doi:10.1111/j.1349-7006.1990.tb02588.x

lck suppresses gene expression from various promoters including human T-cell leukemia virus type I promoter

Jpn J Cancer Res. 1990 May;81(5):440-4. doi: 10.1111/j.1349-7006.1990.tb02588.x.

Authors

M Ohta¹, T Morita, K Shimotohno

Affiliation

¹ Virology Division, National Cancer Center Research Institute, Tokyo.

Abstract

The T-lymphocyte-specific tyrosine kinase gene, lck, is expressed in T-lymphocyte cell lines, except for several human T-cell leukemia virus type I(HTLV-I)-transformed T-lymphocyte cell lines, which produce HTLV-I. By introducing an lck-expression vector, we found that lck product suppresses gene expression from HTLV-I promoter in a transient assay. Moreover, various other promoters of cellular genes or viruses were found to have their transcriptional activity repressed by lck.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chloramphenicol O-Acetyltransferase / biosynthesis
Chloramphenicol O-Acetyltransferase / genetics*
Enzyme Induction
Gene Expression Regulation, Viral*
Human T-lymphotropic virus 1 / genetics*
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Oncogenes*
Protein-Tyrosine Kinases / genetics*
Suppression, Genetic
Transfection

Substances

Chloramphenicol O-Acetyltransferase
Protein-Tyrosine Kinases
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)