Anti-protozoal activity of diamine derivatives

R B Giordani; D P Araújo; M Duarte; J A Zuanazzi; T Tasca; M V De Almeida

doi:10.1016/j.biopha.2010.10.006

Anti-protozoal activity of diamine derivatives

Biomed Pharmacother. 2011 Feb;65(1):60-2. doi: 10.1016/j.biopha.2010.10.006. Epub 2010 Nov 4.

Authors

R B Giordani¹, D P Araújo, M Duarte, J A Zuanazzi, T Tasca, M V De Almeida

Affiliation

¹ Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil.

PMID: 21186095
DOI: 10.1016/j.biopha.2010.10.006

Abstract

Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20μg/mL. N-hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T. vaginalis with MIC of 2.5μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti-G. lamblia activity than MTZ.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiprotozoal Agents / pharmacology*
Diamines / pharmacology*
Giardia lamblia / drug effects
Structure-Activity Relationship
Trichomonas vaginalis / drug effects

Substances

Antiprotozoal Agents
Diamines