Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5

J Immunol. 2011 Feb 1;186(3):1343-7. doi: 10.4049/jimmunol.1002238. Epub 2010 Dec 27.

Abstract

The transcription factor Krüppel-like factor 2 (KLF2) controls the emigration of conventional T cells from the thymus through its regulation of the cell surface receptor S1P1. Prior to KLF2 expression, developing T cells require a positive selection signal through the TCR. However, following positive selection there are time, spatial, and maturational events that occur before KLF2 is finally upregulated and emigration occurs. We are interested in determining the signals that upregulate KLF2 and allow thymocytes to emigrate into circulation and whether they are linked to functional maturation. In endothelial cells KLF2 expression has been shown to be dependent on the mitogen-activated protein kinase ERK5. Furthermore, it has been reported that IL-7 signaling leads to the phosphorylation of ERK5. Thus, we hypothesized that IL-7R signaling through ERK5 could drive the expression of KLF2. In this study, we provide evidence that this hypothesis is incorrect. We also found that CD8 lineage specification occurred normally in the absence of IL-7R signaling, in contrast to a recently proposed model. We showed that both CD4 and CD8 T cells complete maturation and express KLF2 independently of ERK5 and IL-7.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Cell Differentiation / immunology*
  • Cell Movement / genetics
  • Cell Movement / immunology*
  • Interleukin-7 / physiology*
  • Kruppel-Like Transcription Factors / deficiency
  • Kruppel-Like Transcription Factors / genetics
  • Kruppel-Like Transcription Factors / physiology
  • MAP Kinase Signaling System / genetics
  • MAP Kinase Signaling System / immunology
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Mitogen-Activated Protein Kinase 7 / deficiency
  • Mitogen-Activated Protein Kinase 7 / genetics
  • Mitogen-Activated Protein Kinase 7 / physiology*
  • Receptors, Interleukin-7 / antagonists & inhibitors
  • Receptors, Interleukin-7 / deficiency
  • Receptors, Interleukin-7 / genetics
  • T-Lymphocyte Subsets / cytology*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism
  • Thymus Gland / cytology*
  • Thymus Gland / immunology*
  • Thymus Gland / metabolism

Substances

  • Interleukin-7
  • Klf2 protein, mouse
  • Kruppel-Like Transcription Factors
  • Receptors, Interleukin-7
  • Mitogen-Activated Protein Kinase 7