Abstract
Interventions that reduce infarct size in animal models have largely failed to improve outcome in patients suffering acute myocardial infarction (MI), or 'heart attack'. Our group recently reported a reduction of infarct size by chloramphenicol treatment in a porcine in vivo model of acute MI, through a mechanism involving the induction of autophagy. Since 2005 several studies have implicated autophagy as a target for cardioprotection.
MeSH terms
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Animals
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Anti-Infective Agents / pharmacology
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Autophagy
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Chloramphenicol / analogs & derivatives*
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Chloramphenicol / pharmacology
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Clinical Trials as Topic
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Comorbidity
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Coronary Vessels / pathology
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Humans
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Myocardial Infarction / metabolism
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Myocardial Infarction / pathology*
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Myocardium / pathology*
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Placebos
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Swine
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Time Factors
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Treatment Outcome
Substances
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Anti-Infective Agents
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Placebos
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Chloramphenicol
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chloramphenicol succinate