The evaluation of digestive wall lesions has benefited in latter years from advanced, noninvasive techniques such as contrast enhanced ultrasound (CEUS). This method appreciates the microcirculation in inflamed bowel segments in terms of qualitative and quantitative parameters. Based on precise and reproducible criteria it evaluates the extension and the activity of disease, as well as the presence of complications. Monitoring studies using quantitative measurements of inflammation could lead to the development of prognostic factors regarding the treatment efficacy. The performance of this method can be improved by the use of intraluminal contrast media.