Platelet adhesion to collagen

Thromb Res. 2011 Jan:127 Suppl 2:S26-9. doi: 10.1016/S0049-3848(10)70151-1.

Abstract

Platelets play a central role in maintaining hemostasis mainly by binding to subendothelial collagen exposed upon vascular injury, thereby initiating thrombus formation. Platelets can bind directly to the exposed collagen through two major receptors i.e. the integrin a2b1 and glycoprotein (GP) VI. However, under high shear conditions the GPIb-V-IX receptor complex and its main ligand von Willebrand Factor are additionally needed for firm platelet adhesion to the vessel wall. In this review, we summarize the current knowledge on the individual roles and structure-function relationships of these main platelet adhesion receptors.

Publication types

  • Review

MeSH terms

  • Collagen / physiology*
  • Endothelium, Vascular / physiology
  • Hemostasis / physiology
  • Humans
  • Integrin alpha2beta1 / chemistry
  • Integrin alpha2beta1 / physiology
  • Models, Molecular
  • Platelet Adhesiveness / physiology*
  • Platelet Glycoprotein GPIb-IX Complex / chemistry
  • Platelet Glycoprotein GPIb-IX Complex / physiology
  • Platelet Membrane Glycoproteins / chemistry
  • Platelet Membrane Glycoproteins / physiology
  • Protein Structure, Tertiary
  • Thrombosis / blood
  • Thrombosis / etiology
  • Thrombosis / physiopathology
  • von Willebrand Factor / chemistry
  • von Willebrand Factor / physiology

Substances

  • Integrin alpha2beta1
  • Platelet Glycoprotein GPIb-IX Complex
  • Platelet Membrane Glycoproteins
  • platelet membrane glycoprotein VI
  • von Willebrand Factor
  • Collagen