The relevance of assessment of intestinal P-gp inhibition using digoxin as an in vivo probe substrate

Nat Rev Drug Discov. 2011 Jan;10(1):75; author reply 75. doi: 10.1038/nrd3028-c1.
No abstract available

Publication types

  • Letter
  • Comment

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Biological Transport
  • Digoxin / pharmacokinetics
  • Drug Design*
  • Drug Interactions*
  • Humans
  • Intestinal Absorption
  • Intestinal Mucosa / metabolism

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Digoxin