The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology

Bryan Krock; Nicolas Skuli; M Celeste Simon

doi:10.1016/j.cmet.2010.12.015

The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology

Cell Metab. 2011 Jan 5;13(1):8-10. doi: 10.1016/j.cmet.2010.12.015.

Authors

Bryan Krock¹, Nicolas Skuli, M Celeste Simon

Affiliation

¹ Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

PMID: 21195344
DOI: 10.1016/j.cmet.2010.12.015

Abstract

How cellular metabolism regulates stem cell function is poorly understood but is an emerging field of study. In a recent issue of Nature, three independent groups demonstrate that LKB1 promotes hematopoietic stem cell (HSC) quiescence and metabolic homeostasis. Surprisingly, these effects on HSCs occur independently of AMPK/mTOR and FoxO signaling.

Publication types

Comment
Research Support, Non-U.S. Gov't

Grants and funding

Howard Hughes Medical Institute/United States