Anti Ma2-associated myeloradiculopathy: expanding the phenotype of anti-Ma2 associated paraneoplastic syndromes

J Neurol Neurosurg Psychiatry. 2012 Feb;83(2):232-3. doi: 10.1136/jnnp.2010.223271. Epub 2011 Jan 4.

Abstract

Anti-Ma2 associated paraneoplastic syndrome usually presents as limbic encephalitis in association with testicular tumours., Only four patients have been reported with involvement outside the CNS, two of whom also had limbic or brainstem encephalitis., We report a man with anti- Ma2 associated myeloradiculopathy and previous testicular cancer whose neurological syndrome stabilised and anti-Ma2 titres fell following orchidectomy of a microscopically normal testis.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Neoplasm / immunology*
  • Autoantibodies / analysis*
  • Blotting, Western
  • Humans
  • Immunohistochemistry
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Muscle Contraction / physiology
  • Muscle Weakness / etiology
  • Neck Muscles / pathology
  • Nerve Tissue Proteins / immunology*
  • Neurologic Examination
  • Paraneoplastic Syndromes, Nervous System / genetics*
  • Positron-Emission Tomography
  • Radiculopathy / etiology
  • Radiculopathy / immunology*
  • Radiculopathy / pathology
  • Sensation Disorders

Substances

  • Antigens, Neoplasm
  • Autoantibodies
  • Ma2 antigen
  • Nerve Tissue Proteins