Uncapping NF-κB activity in pancreatic cancer

EMBO J. 2011 Jan 5;30(1):1-2. doi: 10.1038/emboj.2010.324.

Abstract

In this issue of The EMBO Journal, Lu et al report on miR-301a as a functional regulator of NF-κB. With miR-301a being itself targeted by NF-κB, the authors unveil a detrimental feed-forward mechanism operating in pancreatic cancer.

Publication types

  • Comment

MeSH terms

  • Gene Expression Regulation, Neoplastic*
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • NF-kappa B / genetics*
  • NF-kappa B / metabolism
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / metabolism
  • Signal Transduction

Substances

  • MicroRNAs
  • NF-kappa B