Glucose-lowering activity of novel tetrasaccharide glyceroglycolipids from the fruits of Cucurbita moschata

Zhiguo Jiang; Qizhen Du

doi:10.1016/j.bmcl.2010.12.030

Glucose-lowering activity of novel tetrasaccharide glyceroglycolipids from the fruits of Cucurbita moschata

Bioorg Med Chem Lett. 2011 Feb 1;21(3):1001-3. doi: 10.1016/j.bmcl.2010.12.030. Epub 2010 Dec 10.

Authors

Zhiguo Jiang¹, Qizhen Du

Affiliation

¹ Institute of Food and Biological Engineering, Zhejiang Gongshang University, Hangzhou, China.

PMID: 21215628
DOI: 10.1016/j.bmcl.2010.12.030

Abstract

Two new tetrasaccharide glyceroglycolipids were obtained from pumpkin. The structures of the two compounds were determined using chemical methods and spectroscopic analysis. Both compounds demonstrated significant glucose-lowering effects in streptozotocin- and high-fat-diet-induced diabetic mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose / analysis
Cucurbita / chemistry*
Diabetes Mellitus, Experimental / chemically induced
Diabetes Mellitus, Experimental / drug therapy
Fruit / chemistry
Glycolipids / chemistry*
Glycolipids / isolation & purification
Glycolipids / therapeutic use
Hypoglycemic Agents / chemistry*
Hypoglycemic Agents / isolation & purification
Hypoglycemic Agents / therapeutic use
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation

Substances

Blood Glucose
Glycolipids
Hypoglycemic Agents
QGMG-2 compound
QGMG-3 compound