The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia

For-Wey Lung; Ming-Chang Yang; Bih-Ching Shu

doi:10.1016/j.psychres.2010.12.025

The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia

Psychiatry Res. 2011 Jul 30;188(2):294-6. doi: 10.1016/j.psychres.2010.12.025. Epub 2011 Jan 8.

Authors

For-Wey Lung¹, Ming-Chang Yang, Bih-Ching Shu

Affiliation

¹ Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan. [email protected]

PMID: 21216474
DOI: 10.1016/j.psychres.2010.12.025

Abstract

A total of 934 patients with schizophrenia and 433 controls were genotyped for the interleukin-10 (IL-10) promoter and DRD4 uVNTR polymorphisms. DRD4 long-form variants (namely, those with ≥5 repeats), homozygosity for the 4-repeat allele, and the IL-10 haplotype ACA were associated with schizophrenia, respectively. No obvious interactions among the potential polymorphisms were found, which suggests that IL-10 and DRD4 confer vulnerability to schizophrenia independently.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Female
Genetic Predisposition to Disease*
Genome-Wide Association Study
Genotype
Humans
Interleukin-10 / genetics*
Male
Minisatellite Repeats / genetics*
Models, Genetic
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics*
Receptors, Dopamine D4 / genetics*
Schizophrenia / genetics*
Taiwan

Substances

DRD4 protein, human
IL10 protein, human
Interleukin-10
Receptors, Dopamine D4