KPC-2 carbapenemase-producing Klebsiella pneumoniae isolates from patients with Cystic Fibrosis

Robson S Leão; Rosana H V Pereira; Tânia W Folescu; Rodolpho M Albano; Erica A Santos; Luiz G C Junior; Elizabeth A Marques

doi:10.1016/j.jcf.2010.12.003

KPC-2 carbapenemase-producing Klebsiella pneumoniae isolates from patients with Cystic Fibrosis

J Cyst Fibros. 2011 Mar;10(2):140-2. doi: 10.1016/j.jcf.2010.12.003. Epub 2011 Jan 8.

Authors

Robson S Leão¹, Rosana H V Pereira, Tânia W Folescu, Rodolpho M Albano, Erica A Santos, Luiz G C Junior, Elizabeth A Marques

Affiliation

¹ Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Brazil.

PMID: 21220216
DOI: 10.1016/j.jcf.2010.12.003

Abstract

Bacteria producing Klebsiella pneumoniae carbapenemases (KPCs) are rapidly emerging as a cause of multidrug-resistant infections worldwide. KPCs enzyme are plasmid-borne and can accumulate and transfer resistance determinants to other classes of antibiotics.We report two cases of KPC-2 carbapenemase-producing Klebsiella pneumoniae isolates from Cystic Fibrosis patients.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Bacterial Proteins / metabolism*
Cystic Fibrosis / microbiology*
Female
Humans
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / enzymology*
Klebsiella pneumoniae / isolation & purification
Young Adult
beta-Lactamases / metabolism*

Substances

Bacterial Proteins
beta-Lactamases
beta-lactamase KPC-2, Klebsiella pneumoniae
carbapenemase-2, Klebsiella pneumoniae