Abstract
We report two cases of venous thrombosis confirmed during the bevacizumab combination chemotherapy for colorectal cancer. Case 1 was a 59-year-old man. We performed an operation for cancer of the rectum. At 2 years after the operation, he received mFOLFOX6 + bevacizumab therapy for a recurrence in the pelvis and lungs metastasis. After the 14th courses, He had a right shoulder pain and contrast enhanced computed tomography revealed deep vein thrombosis to the right arms. Case 2 was a 65-year-old man. We performed an operation for cancer of the rectum. At 6 months after the operation, he received mFOLFOX6 + bevacizumab therapy for lung metastases. After the 6th courses, contrast enhanced computed tomography revealed deep venous and pulmonary thrombosis for both sides, pulmonary thrombosis.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Angiogenesis Inducing Agents / administration & dosage
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Angiogenesis Inducing Agents / adverse effects*
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal, Humanized
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Bevacizumab
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Colorectal Neoplasms / drug therapy*
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Fluorouracil / administration & dosage
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Humans
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Leucovorin / administration & dosage
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Male
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Middle Aged
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Organoplatinum Compounds / administration & dosage
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Pulmonary Embolism / chemically induced
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Rectal Neoplasms / drug therapy
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Venous Thrombosis / chemically induced*
Substances
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Angiogenesis Inducing Agents
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Organoplatinum Compounds
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Bevacizumab
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Leucovorin
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Fluorouracil