Abstract
A novel series of tetraethylene glycol (TEG) triazolyl and squaramide containing oxazolidinones were synthesized and tested for their antibacterial activity against a selected panel of Gram-positive and Gram-negative bacteria. The 4-TEG-triazolyl derivatives were prepared by 'click reaction'. The introduction of the TEG and squaramide groups did not favor antibacterial activity. The three nucleoside-containing oxazolidinones were also prepared by 'click' methodology resulted in weak antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Glycols / chemical synthesis
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Glycols / pharmacology
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Microbial Sensitivity Tests
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Oxazolidinones / chemical synthesis
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Oxazolidinones / chemistry*
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Oxazolidinones / pharmacology*
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Structure-Activity Relationship
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Triazoles / chemical synthesis
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Triazoles / chemistry
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Triazoles / pharmacology
Substances
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Anti-Bacterial Agents
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Glycols
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Oxazolidinones
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Triazoles