Abstract
We have evaluated the effects of the carbon monoxide-releasing molecule CORM-A1 [Na(2) (BH(3) CO(2) ); ALF421] on the development of relapsing-remitting experimental allergic encephalomyelitis (EAE) in SJL mice, an established model of multiple sclerosis (MS). The data show that the prolonged prophylactic administration of CORM-A1 improves the clinical and histopathological signs of EAE, as shown by a reduced cumulative score, shorter duration and a lower cumulative incidence of the disease as well as milder inflammatory infiltrations of the spinal cords. This study suggests that the use of CORM-A1 might represent a novel therapeutic strategy for the treatment of multiple sclerosis.
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / blood
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Body Weight / drug effects
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Boranes / pharmacokinetics
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Boranes / therapeutic use*
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Carbon Monoxide / administration & dosage
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Carbon Monoxide / blood
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Carbon Monoxide / pharmacology
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Carbon Monoxide / therapeutic use*
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Carbonates / pharmacokinetics
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Carbonates / therapeutic use*
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Dexamethasone / pharmacology
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Dexamethasone / therapeutic use
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Encephalomyelitis, Autoimmune, Experimental / diagnosis
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Encephalomyelitis, Autoimmune, Experimental / immunology
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Encephalomyelitis, Autoimmune, Experimental / pathology
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Encephalomyelitis, Autoimmune, Experimental / prevention & control*
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Female
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Mice
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Myelin Proteolipid Protein / immunology*
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Neutrophils / pathology
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Peptide Fragments / immunology*
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Spinal Cord / drug effects
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Spinal Cord / pathology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Boranes
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Carbonates
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Myelin Proteolipid Protein
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Peptide Fragments
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myelin proteolipid protein (139-151)
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sodium boranocarbonate
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Dexamethasone
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Carbon Monoxide