Epigenetic memory meets G2/M: to remember or to forget?

Dev Cell. 2011 Jan 18;20(1):5-6. doi: 10.1016/j.devcel.2010.12.012.

Abstract

The histone H3 lysine 27 (H3K27) methyltransferase EZH2 is essential for stem cell maintenance and proliferation. Recent insights suggest that the cyclin-dependent kinase CDK1 phosphorylates EZH2 at specific threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M phase.

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Proliferation
  • Cyclin-Dependent Kinases / metabolism
  • Epigenomics*
  • G2 Phase / genetics*
  • Histones / metabolism
  • Humans
  • Mitosis / genetics*
  • Models, Biological
  • Phosphorylation
  • Stem Cells / cytology*
  • Stem Cells / metabolism*
  • Transcription Factors / metabolism

Substances

  • Histones
  • Transcription Factors
  • Cyclin-Dependent Kinases