Keratin 15-positive stem cells give rise to basal cell carcinomas in irradiated Ptch1(+/-) mice

John T Seykora; George Cotsarelis

doi:10.1016/j.ccr.2011.01.006

Keratin 15-positive stem cells give rise to basal cell carcinomas in irradiated Ptch1(+/-) mice

Cancer Cell. 2011 Jan 18;19(1):5-6. doi: 10.1016/j.ccr.2011.01.006.

Authors

John T Seykora¹, George Cotsarelis

Affiliation

¹ Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

Abstract

The cell of origin for basal cell carcinoma (BCC) remains controversial. In this issue of Cancer Cell, Wang et al. provide strong evidence that BCC arise from hair follicle stem cells.

Publication types

Comment

Grants and funding

R01 AR051380/AR/NIAMS NIH HHS/United States