Hyperlipidemia-associated pancreatitis in pregnancy managed with fenofibrate

Obstet Gynecol. 2011 Feb;117(2 Pt 2):517-519. doi: 10.1097/AOG.0b013e31820755b5.

Abstract

Background: Pancreatitis is a concerning clinical event during pregnancy, with high morbidity and mortality rates for mother and fetus. Hypertriglyceridemia is considered a rare cause of pancreatitis in pregnancy, with the majority of reported cases being associated with the lipid metabolism disorders.

Case: We report on a case of hypertriglyceridemia-induced pancreatitis in a woman presenting at 32 weeks of gestational age. Her dyslipidemia was not controlled with diet alone, necessitating medical intervention. Fenofibrate was used successfully. Recurrence of pancreatitis during the pregnancy was avoided, and a healthy neonate was delivered at 35 weeks of gestation.

Conclusion: Fenofibrate was used safely and successfully during pregnancy in this case of hypertriglyceridemia-associated pancreatitis refractory to conservative measures.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Glucose / drug effects
  • Female
  • Fenofibrate / therapeutic use*
  • Humans
  • Hypertriglyceridemia / complications
  • Hypertriglyceridemia / diagnosis
  • Hypertriglyceridemia / diet therapy
  • Hypertriglyceridemia / drug therapy*
  • Hypolipidemic Agents / therapeutic use*
  • Infant, Newborn
  • Insulin / therapeutic use
  • Live Birth
  • Male
  • Pancreatitis / diagnosis
  • Pancreatitis / drug therapy*
  • Pancreatitis / etiology
  • Pregnancy
  • Pregnancy Complications / diagnosis
  • Pregnancy Complications / diet therapy
  • Pregnancy Complications / drug therapy*
  • Treatment Outcome

Substances

  • Blood Glucose
  • Hypolipidemic Agents
  • Insulin
  • Fenofibrate