Semi-synthetic polysaccharide sulfates as anticoagulant coatings for PET, 1--cellulose sulfate

Macromol Biosci. 2011 Apr 8;11(4):549-56. doi: 10.1002/mabi.201000419. Epub 2011 Jan 19.

Abstract

In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anticoagulants / chemistry*
  • Cellulose / analogs & derivatives*
  • Cellulose / chemistry
  • Coated Materials, Biocompatible / chemistry*
  • Humans
  • Male
  • Materials Testing*
  • Polyethylene Glycols / chemistry*
  • Polyethylene Terephthalates

Substances

  • Anticoagulants
  • Coated Materials, Biocompatible
  • Polyethylene Terephthalates
  • Polyethylene Glycols
  • Cellulose
  • cellulose sulfate