Abstract
Duramycins B and C, two new lanthionine containing antibiotics, have been isolated from Streptoverticillium strain R2075 and Streptomyces griseoluteus (R2107). The known antibiotics duramycin and cinnamycin were reisolated from Streptoverticillium hachijoense (DSM 40114) and Streptomyces longisporoflavus (DSM 40165). The structures of these latter two compounds should be revised by changing amino acid residue 3 to glutamine and 17 to asparagine, respectively. Cinnamycin therefore seems to be identical to Ro 09-0198. Leucopeptin has been shown to be identical to duramycin. Physico-chemical data of these compounds provide evidence for a similar structure for all duramycin antibiotics. All compounds of this group inhibit human phospholipase A2 at a concentration of 10(-6) molar.
MeSH terms
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Amino Acid Sequence
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Amino Acids / analysis
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Anti-Bacterial Agents* / chemistry*
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Anti-Bacterial Agents* / isolation & purification
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Anti-Bacterial Agents* / pharmacology*
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Antimicrobial Cationic Peptides
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Bacillus subtilis / drug effects
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Bacteriocins
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Chromatography, High Pressure Liquid
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Sequence Data
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Molecular Structure
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Neutrophils / enzymology
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Peptides / chemistry
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Peptides / isolation & purification
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Peptides / pharmacology*
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Peptides, Cyclic*
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Phospholipases A / antagonists & inhibitors*
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Phospholipases A2
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Protein Conformation
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Stereoisomerism
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Streptomyces / classification
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Streptomyces / metabolism
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Streptomycetaceae / classification
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Streptomycetaceae / metabolism
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Structure-Activity Relationship
Substances
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Amino Acids
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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Bacteriocins
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Peptides
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Peptides, Cyclic
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duramycin B
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duramycin C
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duramycin
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cinnamycin
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Phospholipases A
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Phospholipases A2