Cognitive development in Dravet syndrome: a retrospective, multicenter study of 26 patients

Epilepsia. 2011 Feb;52(2):386-92. doi: 10.1111/j.1528-1167.2010.02925.x. Epub 2011 Jan 26.

Abstract

Purpose: To clarify the role of epilepsy and genetic background in determining the cognitive outcome of patients with Dravet syndrome.

Methods: In this retrospective study, we reviewed the clinical history and cognitive development of 26 patients who had been followed with standardized evaluations since seizure onset. The cognitive outcome was quantified as differential general quotient (dGQ) between ages 12 and 60 months. Statistical analysis correlated the dGQ with genotype and epilepsy course.

Key findings: Epilepsy started at the mean age of 5.6 months. All patients experienced prolonged convulsive seizures, whereas absences and myoclonus were reported in 17. Cognitive outcome was poor in almost all patients; the mean dGQ was 33 points, varying from 6-77 points. The analysis of individual cognitive profiles identified seven patients in whom the dGQ was <20 points; the main clinical characteristic in this subset of patients was lack of early absences and myoclonus. The statistical analysis of the whole series failed to reveal significant differences in cognitive outcome with regard to the presence of SCN1A mutations and their type. In particular, mutation-carrier patients with the best cognitive outcome harbored either missense or truncating mutations.

Significance: Dravet syndrome encompasses different epileptic and cognitive phenotypes that probably result from both genetic and epigenetic factors. In this series, early appearance of myoclonus and absences was associated with the worst cognitive outcome.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age of Onset
  • Child
  • Child Development / physiology*
  • Child, Preschool
  • Cognition / physiology*
  • Electroencephalography
  • Female
  • Genotype
  • Heterozygote
  • Humans
  • Infant
  • Italy
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Mutation / physiology
  • Myoclonic Epilepsy, Juvenile / genetics*
  • Myoclonic Epilepsy, Juvenile / psychology*
  • NAV1.1 Voltage-Gated Sodium Channel
  • Nerve Tissue Proteins / genetics
  • Retrospective Studies
  • Seizures / complications
  • Seizures / genetics
  • Sodium Channels / genetics
  • Status Epilepticus / complications
  • Status Epilepticus / genetics

Substances

  • NAV1.1 Voltage-Gated Sodium Channel
  • Nerve Tissue Proteins
  • SCN1A protein, human
  • Sodium Channels