CNS autoimmune inflammation: RICK must NOD!

Zizhen Kang; Muhammet Fatih Gulen; Xiaoxia Li

doi:10.1016/j.immuni.2011.01.010

CNS autoimmune inflammation: RICK must NOD!

Immunity. 2011 Jan 28;34(1):3-5. doi: 10.1016/j.immuni.2011.01.010.

Authors

Zizhen Kang¹, Muhammet Fatih Gulen, Xiaoxia Li

Affiliation

¹ Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Abstract

In this issue of Immunity, Shaw et al. (2011) report that the NOD-RICK signaling axis is required for the activation of dendritic cells infiltrating the central nervous system, leading to reactivation of antigen-specific T cells and autoimmune inflammation.

Publication types

Comment

Grants and funding

P01 HL029582/HL/NHLBI NIH HHS/United States