Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1

ChemMedChem. 2011 Feb 7;6(2):258-61. doi: 10.1002/cmdc.201000483. Epub 2010 Dec 16.

Authors

Jerome Wielens¹, Stephen J Headey, John J Deadman, David I Rhodes, Giang T Le, Michael W Parker, David K Chalmers, Martin J Scanlon

Affiliation

¹ Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Australia.

PMID: 21275048
DOI: 10.1002/cmdc.201000483

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Binding Sites
Catalysis
HIV Integrase / drug effects*
HIV Integrase / metabolism
Hydrogen Bonding
Ligands
Magnetic Resonance Spectroscopy
Models, Molecular

Substances

Ligands
HIV Integrase
p31 integrase protein, Human immunodeficiency virus 1