Abstract
Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspergillus fumigatus / cytology*
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Aspergillus fumigatus / enzymology*
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Aspergillus fumigatus / genetics
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Aspergillus fumigatus / growth & development*
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Cell Polarity*
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Cell Shape
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Fungal Proteins / genetics
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Fungal Proteins / metabolism*
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Hyphae / metabolism
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Hyphae / ultrastructure
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ras Proteins / genetics
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ras Proteins / metabolism*
Substances
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Fungal Proteins
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ras Proteins