Dysfunctions of the Iga system: a common link between intestinal and renal diseases

Cell Mol Immunol. 2011 Mar;8(2):126-34. doi: 10.1038/cmi.2010.69. Epub 2011 Jan 31.

Abstract

Immunoglobulin A (Iga)-isotype antibodies play an important role in immunity owing to their structure, glycosylation, localization and receptor interactions. Dysfunctions in this system can lead to multiple types of pathology. This review describes the characteristics of Iga and discusses the involvement of abnormalities in the Iga system on the development of celiac disease and Iga nephropathy.

Publication types

  • Review

MeSH terms

  • Celiac Disease / immunology*
  • Celiac Disease / physiopathology*
  • Glomerulonephritis, IGA / immunology*
  • Glomerulonephritis, IGA / physiopathology*
  • Humans
  • Immunoglobulin A / biosynthesis
  • Immunoglobulin A / chemistry
  • Immunoglobulin A / immunology*
  • Receptors, Immunologic / immunology

Substances

  • Immunoglobulin A
  • Receptors, Immunologic