Targeting bacterial biofilms: design of a terpenoid-like library as non-toxic anti-biofilm compounds

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1493-7. doi: 10.1016/j.bmcl.2010.12.134. Epub 2011 Jan 13.

Abstract

A new class of anti-biofilm compounds possessing 1,4-disubstituted-(1H)-1,2,3-triazolic cores was designed. Their efficient synthesis was performed by means of click chemistry through 1,3-dipolar cycloadditions. Two compounds were found to act as specific anti-biofilm agents against a gram negative species.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Bacteria / drug effects
  • Biofilms / drug effects*
  • Drug Delivery Systems*
  • Drug Design*
  • Terpenes / chemical synthesis*
  • Terpenes / chemistry
  • Terpenes / pharmacology
  • Triazoles / chemistry

Substances

  • Anti-Bacterial Agents
  • Terpenes
  • Triazoles