A new and general one-pot synthesis of propargyl alcohols from esters

Min Jung Chae; Ah Ram Jeon; Tom Livinghouse; Duk Keun An

doi:10.1039/c0cc04597g

A new and general one-pot synthesis of propargyl alcohols from esters

Chem Commun (Camb). 2011 Mar 21;47(11):3281-3. doi: 10.1039/c0cc04597g. Epub 2011 Feb 1.

Authors

Min Jung Chae¹, Ah Ram Jeon, Tom Livinghouse, Duk Keun An

Affiliation

¹ Department of Chemistry, Kangwon National University, and Institute for Molecular Science and Fusion Technology, Chuncheon 200-701, Korea.

PMID: 21286619
DOI: 10.1039/c0cc04597g

Abstract

Intermediates easily prepared by partial reduction of various esters with LDBBA as a reducing agent smoothly react with lithium acetylides to give propargyl alcohols, without isolation of partial reduction intermediates, in good yields (73-83%).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemical synthesis
Alkynes / chemistry*
Esters
Lithium / chemistry
Oxidation-Reduction
Propanols / chemical synthesis
Propanols / chemistry*

Substances

Alkynes
Esters
Propanols
Lithium
propargyl alcohol