Abstract
During April 2009-June 2010, thirty-seven (0.5%) of 6,740 pandemic (H1N1) 2009 viruses submitted to a US surveillance system were oseltamivir resistant. Most patients with oseltamivir-resistant infections were severely immunocompromised (76%) and had received oseltamivir before specimen collection (89%). No evidence was found for community circulation of resistant viruses; only 4 (unlinked) patients had no oseltamivir exposure.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Antiviral Agents / administration & dosage
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Antiviral Agents / pharmacology*
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Child
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Child, Preschool
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Drug Resistance, Viral*
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Enzyme Inhibitors / administration & dosage
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Enzyme Inhibitors / pharmacology
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Female
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Humans
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Immunocompromised Host
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Infant
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Influenza A Virus, H1N1 Subtype / drug effects*
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Influenza A Virus, H1N1 Subtype / pathogenicity
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Influenza, Human* / epidemiology
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Influenza, Human* / mortality
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Influenza, Human* / physiopathology
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Influenza, Human* / virology
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Male
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Middle Aged
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Neuraminidase / antagonists & inhibitors
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Oseltamivir / administration & dosage
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Oseltamivir / pharmacology*
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Pandemics*
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Population Surveillance / methods
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United States / epidemiology
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Young Adult
Substances
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Antiviral Agents
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Enzyme Inhibitors
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Oseltamivir
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Neuraminidase