Abstract
A 60-year-old woman was found to have proteinuria and a lung nodule. The surgically resected left upper lobe contained a nodule, in which the adenocarcinoma was surrounded by a heavy deposition of amyloid. Subsequent renal and gastric biopsies demonstrated amyloid deposition with Aλ immunoreactivity. She was treated with 2 courses of VAD (vincristine, doxorubicin and dexamethasone), resulting in the disappearance of Bence Jones proteinuria. Her nephrotic syndrome has been improving during the subsequent 3 years. The rare lung nodule consisting of adenocarcinoma and amyloid deposition was a diagnostic clue in this primary systemic AL amyloidosis patient.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenocarcinoma / diagnosis*
-
Adenocarcinoma / metabolism*
-
Adenocarcinoma / therapy
-
Amyloid / metabolism*
-
Amyloidosis / complications*
-
Amyloidosis / diagnosis*
-
Antineoplastic Combined Chemotherapy Protocols
-
Biopsy
-
Combined Modality Therapy
-
Dexamethasone / therapeutic use
-
Doxorubicin / therapeutic use
-
Female
-
Gastric Mucosa / metabolism
-
Humans
-
Kidney / metabolism
-
Kidney / pathology
-
Lung Neoplasms / diagnosis*
-
Lung Neoplasms / metabolism*
-
Lung Neoplasms / therapy
-
Middle Aged
-
Pneumonectomy
-
Stomach / pathology
-
Treatment Outcome
-
Vincristine / therapeutic use
Substances
-
Amyloid
-
Vincristine
-
Dexamethasone
-
Doxorubicin