Abstract
Azole resistance is an increasing clinical problem for Aspergillus fumigatus, with the majority of published resistance arising from mutations in the azole target gene CYP51A. Previous structural studies of this protein have suffered from a nonorthologous, low-homology template for homology modeling. Here we present a new model based on the human CYP51A orthologue that provides a higher-quality model for A. fumigatus CYP51A.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Aspergillus fumigatus / drug effects*
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Aspergillus fumigatus / genetics*
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Azoles / chemistry
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Azoles / pharmacology*
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Cytochrome P-450 Enzyme System / genetics*
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Drug Resistance, Fungal / genetics
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Fungal Proteins / genetics*
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Molecular Structure
Substances
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Antifungal Agents
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Azoles
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Fungal Proteins
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Cytochrome P-450 Enzyme System
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cytochrome P-450 CYP51A, Aspergillus