Abstract
Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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AIDS Dementia Complex / metabolism*
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AIDS Dementia Complex / pathology
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AIDS Dementia Complex / virology
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Algorithms
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Atrophy
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Automation, Laboratory
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Brain / metabolism*
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Brain / pathology
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Brain / virology
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CD4-Positive T-Lymphocytes / pathology
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Cell Count
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Cognition
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Cone-Beam Computed Tomography / methods*
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Female
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HIV / physiology
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HIV Infections / metabolism
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HIV Infections / pathology
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HIV Infections / virology
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Humans
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Magnetic Resonance Imaging / methods*
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Male
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Matrix Metalloproteinase 2 / biosynthesis
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Matrix Metalloproteinase 2 / cerebrospinal fluid
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Matrix Metalloproteinase 7* / biosynthesis
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Matrix Metalloproteinase 7* / cerebrospinal fluid
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Middle Aged
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Viral Load
Substances
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Matrix Metalloproteinase 7
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Matrix Metalloproteinase 2