Kaurane-type diterpenoids from Chromoleana odorata, their X-ray diffraction studies and potent α-glucosidase inhibition of 16-kauren-19-oic acid

Fitoterapia. 2011 Jun;82(4):642-6. doi: 10.1016/j.fitote.2011.02.003. Epub 2011 Feb 21.

Abstract

A new diterpenoid, 15-angeloyloxy-16,17-epoxy-19-kauronic acid (1), along with five known metabolites, 16-kauren-19-oic acid (2), 6'-hydroxy-2',3',4,4'-tetramethoxychalcone (3), isosakuranetin (4), acacetin (5), and kaempferide (6) was isolated from the organic extracts of the roots of Chromoleana odorata. Their structures were determined by spectroscopic evidences. The structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction studies. Compound 2 exhibited significant α-glucosidase inhibitory and antibacterial activities against Escherichia coli and Bacillus subtilis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / analysis*
  • Chromolaena / chemistry*
  • Diterpenes, Kaurane / chemistry
  • Diterpenes, Kaurane / isolation & purification*
  • Glycoside Hydrolase Inhibitors*
  • Microbial Sensitivity Tests
  • Plant Roots / chemistry
  • X-Ray Diffraction

Substances

  • 15-angeloyloxy-16,17-epoxy-19-kauronic acid
  • 16-kauren-19-oic acid
  • Anti-Bacterial Agents
  • Diterpenes, Kaurane
  • Glycoside Hydrolase Inhibitors