Abstract
A pharmacokinetic analysis was performed for single intravenous doses of daptomycin 8 or 10 mg/kg in subjects aged 2 to 6 years. Proportional increases in maximum plasma concentration (68.4 μg/mL, 79.2 μg/mL) and area under the curve (429.1 μg · h/mL, 549.7 μg · h/mL) were observed for each dose cohort, respectively. Half-life, clearance, and distribution volume were similar between groups. Both doses were well tolerated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / pharmacokinetics*
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Area Under Curve
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Biological Availability
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Child
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Child, Preschool
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Daptomycin / administration & dosage
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Daptomycin / adverse effects*
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Daptomycin / pharmacokinetics*
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Female
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Gram-Positive Bacterial Infections / drug therapy*
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Half-Life
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Humans
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Injections, Intravenous
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Male
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Metabolic Clearance Rate
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Plasma / chemistry
Substances
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Anti-Bacterial Agents
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Daptomycin