CD4+CD28 null T lymphocytes are expanded in young women with polycystic ovary syndrome

Fertil Steril. 2011 Jun 30;95(8):2651-4. doi: 10.1016/j.fertnstert.2011.01.129. Epub 2011 Feb 16.

Abstract

Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4(+)CD28(null) T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

MeSH terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Biomarkers / blood
  • C-Reactive Protein / analysis
  • CD28 Antigens / metabolism*
  • CD4-Positive T-Lymphocytes / immunology*
  • Cardiovascular Diseases / immunology*
  • Case-Control Studies
  • Cell Proliferation*
  • Female
  • Humans
  • Hyperinsulinism / immunology
  • Inflammation Mediators / blood
  • Italy
  • Linear Models
  • Polycystic Ovary Syndrome / complications
  • Polycystic Ovary Syndrome / immunology*
  • Risk Assessment
  • Risk Factors
  • Young Adult

Substances

  • Biomarkers
  • CD28 Antigens
  • Inflammation Mediators
  • C-Reactive Protein